6-Shogaol-Loaded Transferosomal Transdermal Patches: Extraction, Formulation, and Evaluation for Targeted Anticancer Therapy

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Authors

Simanchal Panda
School of Pharmaceutical Sciences, Jaipur National University, Rajasthan, India
https://orcid.org/0000-0003-1494-7628
Ajit Kumar Ngangbam
Post Doctoral Department, Manipur International University, Manipur, India
https://orcid.org/0000-0001-5013-5235

Keywords:

6-Shogaol, Transferosomes, Transdermal patch, Targeted drug delivery, Anticancer therapy, Nanoparticles, Nanotechnology

Synopsis

6-Shogaol, a bioactive ginger-derived phenolic compound with reported anticancer activity, suffers from poor aqueous solubility and limited bioavailability that hinder systemic delivery. This study aimed to formulate and evaluate 6-Shogaol-loaded transferosomes and incorporate them into transdermal patches to achieve sustained, targeted dermal delivery for anticancer therapy. Transferosomes were prepared by the thin-film hydration method using phospholipids and edge-activators, and optimized for vesicle size, polydispersity, zeta potential and entrapment efficiency. Optimized vesicles were characterized by dynamic light scattering and transmission electron microscopy, then loaded into a polymeric matrix by solvent-casting to produce transdermal patches. The prepared transdermal patches underwent assessment for their physicochemical characteristics, including parameters such as thickness, weight consistency, and folding durability, tensile strength, surface pH), drug content and in vitro release. Ex vivo permeation across excised mammalian skin and skin retention studies were performed to assess transdermal delivery potential. In vitro cytotoxicity and cell-viability assays on representative cancer cell lines were used to compare the anticancer efficacy of 6-Shogaol in transferosomal patches versus free drug. Stability studies under accelerated conditions evaluated formulation integrity. Results demonstrated that transferosomes provided high encapsulation of 6-Shogaol, nanosized uniform vesicles, and improved drug deposition in skin with sustained release from the patch matrix. Ex vivo permeation and cytotoxicity data indicated enhanced transdermal delivery and greater anticancer activity compared with non-encapsulated drug. The developed 6-Shogaol transferosomal transdermal patch shows promise as a non-invasive platform for sustained, targeted anticancer therapy and warrants further preclinical investigation.

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Published

11 August 2025
Copyright (c) 2025 Simanchal Panda, Ajit Kumar Ngangbam

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E-Book

ISBN-13 (15)

978-93-7185-806-9

Details about the available publication format: Book (Paperback)

Book (Paperback)

ISBN-13 (15)

978-93-7185-639-3

How to Cite

Panda, S. ., & Ngangbam, A. K. . (2025). 6-Shogaol-Loaded Transferosomal Transdermal Patches: Extraction, Formulation, and Evaluation for Targeted Anticancer Therapy. Deep Science Publishing. https://doi.org/10.70593/978-93-7185-806-9
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