In-Vitro Biological Assessment of Basic Indole Derivatives

This book provides an in-depth study of the synthesis, characterization, and biological evaluation of newly designed Schiff bases derived from N-benzyl isatin. This book primarily focuses on addressing inflammation and pain, two significant concerns in therapeutic research. Through a carefully structured synthetic strategy, we developed a series of derivatives and validated their structures using advanced analytical techniques such as FT-IR spectroscopy, ¹H-NMR, UV-Visible spectrometry, and Thin Layer Chromatography. Their anti-inflammatory efficacy was assessed through an in-vitro protein denaturation method, offering important preliminary insights into their biological potential. This study bridges the fields of synthetic organic chemistry and pharmacological evaluation, highlighting the importance of interdisciplinary approaches in modern drug discovery. A detailed examination of the relationship between structural modifications and biological activity forms a core part of this research.

We believe this book will serve as a valuable reference for researchers, students, and professionals in medicinal chemistry, pharmaceutical sciences, and related disciplines. We are deeply grateful to all those who supported and encouraged this work. It is our hope that the findings presented here will inspire further research and spark new ideas in the field of drug design and development.