Stimuli responsive polymers used in drug delivery systems

Smart polymers, frequently referred to as stimuli-responsive polymers that are they have evolved into a unique new material for the design of advanced drug delivery system. These polymers undergo fast, reversible physicochemical change in rejoinder to external impetuses redox potential, and individual biomolecules. Stimuli-responsive polymers can transform to responsive drug carriers that can be triggered using external environmental stimuli for on-site, controlled, and demand release of a drug, cumulative beneficial value while dropping systemic side effects. This chapter describes the numerous types and their modes of action and functional roles in the field of drug delivery systems. Focused attention on certain classes of single and dual-stimuli responsive systems, synthetic routes for polymers, and updates on nanocarrier-based formulations in regards to stimuli-responsive polymers. Lastly, we describe a few key clinical applications, challenges and opportunities at the present, and vision for stimuli-responsive polymeric drug delivery systems as they have the potential to reshape precision medicine and individualized therapeutics.